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KMID : 1123920060200041036
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 4 p.1036 ~ p.1043
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Regulatory Effects of Gamisamul-tang on Atopic Dermatitis Induced in the NC/Nga Mice
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Yang Sun-Sim
Nam Gung-Uk
Kim Dong-Hee
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Abstract
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The present study was conducted to investigate the effect of Gamisamul-tang (GSMT) on atopic dermatitis (AD). AD was induced in NC/Nga mutant mice by DNCB treatment. GSMT administration reduced levels of skin severity scores. Serum levels of IgE, IgG, IgM, and inflammatory cytokines including IL-4, IL-4 and 1L-13 were significantly decreased by GSMT treatment. Levels of mRNA’s encoding IL-4, IL-6, IL-13, , and in the dermal tissue and draining lymph node (DLN) by real time RT-PCR analysis showed decrease by GSMT testament. Moreover, the number of CD4+ and CD8+ cells was significantly decreased in the spleen and DLN tissues. Histological examination showed that infiltration levels of immune cells in ear, skin, and DLN of AD-induced NC/Nga mice were much improved by GSMT treatment. The present data suggest that GSMT may play an important role in recovering AD symptoms by regulating immune reactivity.
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KEYWORD
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Gamisamul-tang, NC/Nga mouse, Atopic dermatitis, RT-PCR, inflammatory cytokine
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